Haplotype inference for present–absent genotype data using previously identified haplotypes and haplotype patterns
نویسندگان
چکیده
منابع مشابه
Haplotype inference for present-absent genotype data using previously identified haplotypes and haplotype patterns
MOTIVATION Killer immunoglobulin-like receptor (KIR) genes vary considerably in their presence or absence on a specific regional haplotype. Because presence or absence of these genes is largely detected using locus-specific genotyping technology, the distinction between homozygosity and hemizygosity is often ambiguous. The performance of methods for haplotype inference (e.g. PL-EM, PHASE) for K...
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The majority of killer cell immunoglobin-like receptor (KIR) genes are detected as either present or absent using locus-specific genotyping technology. Ambiguity arises from the presence of a specific KIR gene since the exact copy number (one or two) of that gene is unknown. Therefore, haplotype inference for these genes is becoming more challenging due to such large portion of missing informat...
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With the rapid progress of genotyping techniques, many large-scale, genome-wide disease studies are now under way. One of the challenges of large disease-association studies is developing a fast and accurate computing method for haplotype inference from genotype data. In this paper, a new computing method for population-based haplotype inference problem is proposed. The designed method does not...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2007
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btm371